Publication: Angiopoietin-2, marker and mediator of endothelial activation with prognostic significance early after trauma
Angiopoietin-2, marker and mediator of endothelial activation with prognostic significance early after trauma
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Ganter, M. T., Cohen, M. J., Brohi, K., Chesebro, B. B., Staudenmayer, K. L., Rahn, P., Christiaans, S. C., Bir, N. D., & Pittet, J. F. (2008). Angiopoietin-2, marker and mediator of endothelial activation with prognostic significance early after trauma. Annals of Surgery, 247(2), 320–326. https://doi.org/10.1097/SLA.0b013e318162d616
Abstract
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OBJECTIVE: To measure plasma levels of angiopoietin-1 (Ang-1), angiopoietin-2 (Ang-2), and vascular endothelial growth factor (VEGF) early after trauma and to determine their clinical significance. BACKGROUND: Angiopoietins and VEGF play a central role in the physiology and pathophysiology of endothelial cells. Ang-2 has recently been shown to have pathogenetic significance in sepsis and acute lung injury. Little is known about the role of angiopoietins and VEGF early after trauma. METHODS: Blood specimens from consecutive major traum
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- Ganter, M T
- Cohen, M J
- Brohi, K
- Chesebro, B B
- Staudenmayer, K L
- Rahn, P
- Christiaans, S C
- Bir, N D
- Pittet, J F
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Ganter, M. T., Cohen, M. J., Brohi, K., Chesebro, B. B., Staudenmayer, K. L., Rahn, P., Christiaans, S. C., Bir, N. D., & Pittet, J. F. (2008). Angiopoietin-2, marker and mediator of endothelial activation with prognostic significance early after trauma. Annals of Surgery, 247(2), 320–326. https://doi.org/10.1097/SLA.0b013e318162d616
