Publication: The human RecQ helicases BLM and RECQL4 cooperate to preserve genome stability
The human RecQ helicases BLM and RECQL4 cooperate to preserve genome stability
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Singh, D. K., Popuri, V., Kulikowicz, T., Shevelev, I., Ghosh, A. K., Ramamoorthy, M., Rossi, M. L., Janscak, P., Croteau, D. L., & Bohr, V. A. (2012). The human RecQ helicases BLM and RECQL4 cooperate to preserve genome stability. Nucleic Acids Research, 40, 6632–6648. https://doi.org/10.1093/nar/gks349
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Bacteria and yeast possess one RecQ helicase homolog whereas humans contain five RecQ helicases, all of which are important in preserving genome stability. Three of these, BLM, WRN and RECQL4, are mutated in human diseases manifesting in premature aging and cancer. We are interested in determining to which extent these RecQ helicases function cooperatively. Here, we report a novel physical and functional interaction between BLM and RECQL4. Both BLM and RECQL4 interact in vivo and in vitro. We have mapped the BLM interacting site to th
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- Singh, Dharmendra Kumar
- Popuri, Venkateswarlu
- Kulikowicz, Tomasz
- Shevelev, Igor
- Ghosh, Avik K
- Ramamoorthy, Mahesh
- Rossi, Marie L
- Janscak, Pavel
- Croteau, Deborah L
- Bohr, Vilhelm A
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Singh, D. K., Popuri, V., Kulikowicz, T., Shevelev, I., Ghosh, A. K., Ramamoorthy, M., Rossi, M. L., Janscak, P., Croteau, D. L., & Bohr, V. A. (2012). The human RecQ helicases BLM and RECQL4 cooperate to preserve genome stability. Nucleic Acids Research, 40, 6632–6648. https://doi.org/10.1093/nar/gks349
