Functionality testing of stem cell grafts to predict infectious complications after allogeneic hematopoietic stem cell transplantation

Nilsson, J; Granrot, I; Mattsson, J; Omazic, B; Uhlin, M; Thunberg, S

doi:10.1111/Vox.12521

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Nilsson, J., Granrot, I., Mattsson, J., Omazic, B., Uhlin, M., & Thunberg, S. (2017). Functionality testing of stem cell grafts to predict infectious complications after allogeneic hematopoietic stem cell transplantation. Vox Sanguinis, 112(5), 459–468. https://doi.org/10.1111/Vox.12521

Abstract

BACKGROUND AND OBJECTIVES: Allogeneic hematopoietic stem cell transplantation (HSCT) is a routine clinical procedure performed to treat patients with haematological malignancies, primary immune deficiencies or metabolic disorders. Infections during lymphopenia after allogeneic HSCT are associated with high mortality and morbidity. Typical infectious agents are Epstein-Barr virus, cytomegalovirus, herpes simplex virus, varicella-zoster virus and fungi. The study aim was to evaluate whether measurement of the responses of antigen-spec