Publication: Analysis of AR/ARV7 Expression in Isolated Circulating Tumor Cells of Patients with Metastatic Castration-Resistant Prostate Cancer (SAKK 08/14 IMPROVE Trial)
Analysis of AR/ARV7 Expression in Isolated Circulating Tumor Cells of Patients with Metastatic Castration-Resistant Prostate Cancer (SAKK 08/14 IMPROVE Trial)
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Hench, I. B., Cathomas, R., Costa, L., Fischer, N., Gillessen, S., Hench, J., Hermanns, T., Kremer, E., Mingrone, W., Mestre, R. P., Püschel, H., Rothermundt, C., Ruiz, C., Tolnay, M., Von Burg, P., Bubendorf, L., & Vlajnic, T. (2019). Analysis of AR/ARV7 Expression in Isolated Circulating Tumor Cells of Patients with Metastatic Castration-Resistant Prostate Cancer (SAKK 08/14 IMPROVE Trial). Cancers, 11, E1099. https://doi.org/10.3390/cancers11081099
Abstract
Abstract
Abstract
Despite several treatment options and an initial high response rate to androgen deprivation therapy, the majority of prostate cancers will eventually become castration-resistant in the metastatic stage (mCRPC). Androgen receptor splice variant 7 (ARV7) is one of the best-characterized androgen receptor (AR) variants whose expression in circulating tumor cells (CTCs) has been associated with enzalutamide resistance. ARV7 expression analysis before and during enzalutamide treatment could identify patients requiring alternative systemic
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Creators (Authors)
- Hench, Ivana Bratic
- Cathomas, Richard
- Costa, Luigi
- Fischer, Natalie
- Gillessen, Silke
- Hench, Jürgen
- Hermanns, Thomas
- Kremer, Eloïse
- Mingrone, Walter
- Mestre, Ricardo Pereira
- Püschel, Heike
- Rothermundt, Christian
- Ruiz, Christian
- Tolnay, Markus
- Von Burg, Philippe
- Bubendorf, Lukas
- Vlajnic, Tatjana
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Hench, I. B., Cathomas, R., Costa, L., Fischer, N., Gillessen, S., Hench, J., Hermanns, T., Kremer, E., Mingrone, W., Mestre, R. P., Püschel, H., Rothermundt, C., Ruiz, C., Tolnay, M., Von Burg, P., Bubendorf, L., & Vlajnic, T. (2019). Analysis of AR/ARV7 Expression in Isolated Circulating Tumor Cells of Patients with Metastatic Castration-Resistant Prostate Cancer (SAKK 08/14 IMPROVE Trial). Cancers, 11, E1099. https://doi.org/10.3390/cancers11081099
