Publication: Evaluation of the antiviral efficacy of bis[1,2]dithiolo[1,4]thiazines and bis[1,2]dithiolopyrrole derivatives against the nucelocapsid protein of the Feline Immunodeficiency Virus (FIV) as a model for HIV infection
Evaluation of the antiviral efficacy of bis[1,2]dithiolo[1,4]thiazines and bis[1,2]dithiolopyrrole derivatives against the nucelocapsid protein of the Feline Immunodeficiency Virus (FIV) as a model for HIV infection
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Asquith, C. R. M., Meli, M. L., Konstantinova, L. S., Laitinen, T., Peräkylä, M., Poso, A., Rakitin, O. A., Allenspach, K., Hofmann-Lehmann, R., & Hilton, S. T. (2014). Evaluation of the antiviral efficacy of bis[1,2]dithiolo[1,4]thiazines and bis[1,2]dithiolopyrrole derivatives against the nucelocapsid protein of the Feline Immunodeficiency Virus (FIV) as a model for HIV infection. Bioorganic & Medicinal Chemistry Letters, 24(12), 2640–2644. https://doi.org/10.1016/j.bmcl.2014.04.073
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A diverse library of bis[1,2]dithiolo[1,4]thiazines and bis[1,2]dithiolopyrrole derivatives were prepared for evaluation of activity against the nucleocapsid protein of the Feline Immunodeficiency Virus (FIV) as a model for HIV, using an in vitro cell culture approach, yielding nanomolar active compounds with low toxicity.
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- Asquith, Christopher R M
- Meli, Marina L
- Konstantinova, Lidia S
- Laitinen, Tuomo
- Peräkylä, Mikael
- Poso, Antti
- Rakitin, Oleg A
- Allenspach, Karin
- Hilton, Stephen T
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Asquith, C. R. M., Meli, M. L., Konstantinova, L. S., Laitinen, T., Peräkylä, M., Poso, A., Rakitin, O. A., Allenspach, K., Hofmann-Lehmann, R., & Hilton, S. T. (2014). Evaluation of the antiviral efficacy of bis[1,2]dithiolo[1,4]thiazines and bis[1,2]dithiolopyrrole derivatives against the nucelocapsid protein of the Feline Immunodeficiency Virus (FIV) as a model for HIV infection. Bioorganic & Medicinal Chemistry Letters, 24(12), 2640–2644. https://doi.org/10.1016/j.bmcl.2014.04.073