Publication: Functional, Metabolic and Morphologic Results of Ex Vivo Donor Lung Perfusion with a Perfluorocarbon-Based Oxygen Carrier Nanoemulsion in a Large Animal Transplantation Model
Functional, Metabolic and Morphologic Results of Ex Vivo Donor Lung Perfusion with a Perfluorocarbon-Based Oxygen Carrier Nanoemulsion in a Large Animal Transplantation Model
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Inci, I., Arni, S., Iskender, I., Citak, N., Rodriguez, J. M., Weisskopf, M., Opitz, I., Weder, W., Frauenfelder, T., Krafft, M. P., & Spahn, D. R. (2020). Functional, Metabolic and Morphologic Results of Ex Vivo Donor Lung Perfusion with a Perfluorocarbon-Based Oxygen Carrier Nanoemulsion in a Large Animal Transplantation Model. Cells, 9(11), 2501. https://doi.org/10.3390/cells9112501
Abstract
Abstract
Abstract
BACKGROUND
Ex vivo lung perfusion (EVLP) is a technology that allows the re-evaluation of questionable donor lung before implantation and it has the potential to repair injured donor lungs that are otherwise unsuitable for transplantation. We hypothesized that perfluorocarbon-based oxygen carrier, a novel reconditioning strategy instilled during EVLP would improve graft function.
METHODS
We utilized perfluorocarbon-based oxygen carrier (PFCOC) during EVLP to recondition and improve lung graft function in a pig model of EVLP and lun
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Creators (Authors)
- Inci, Ilhan
- Arni, Stephan
- Iskender, Ilker
- Citak, Necati
- Rodriguez, Josep Monné
- Weisskopf, Miriam
- Opitz, Isabelle
- Weder, Walter
- Frauenfelder, Thomas
- Krafft, Marie Pierre
- Spahn, Donat R
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Citations
Inci, I., Arni, S., Iskender, I., Citak, N., Rodriguez, J. M., Weisskopf, M., Opitz, I., Weder, W., Frauenfelder, T., Krafft, M. P., & Spahn, D. R. (2020). Functional, Metabolic and Morphologic Results of Ex Vivo Donor Lung Perfusion with a Perfluorocarbon-Based Oxygen Carrier Nanoemulsion in a Large Animal Transplantation Model. Cells, 9(11), 2501. https://doi.org/10.3390/cells9112501
