Publication: Distribution of EGFR amplification, combined chromosome 7 gain and chromosome 10 loss, and TERT promoter mutation in brain tumors and their potential for the reclassification of IDHwt astrocytoma to glioblastoma
Distribution of EGFR amplification, combined chromosome 7 gain and chromosome 10 loss, and TERT promoter mutation in brain tumors and their potential for the reclassification of IDHwt astrocytoma to glioblastoma
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Stichel, D., Ebrahimi, A., Reuss, D., Schrimpf, D., Ono, T., Shirahata, M., Reifenberger, G., Weller, M., Hänggi, D., Wick, W., Herold-Mende, C., Westphal, M., Brandner, S., Pfister, S. M., Capper, D., Sahm, F., & von Deimling, A. (2018). Distribution of EGFR amplification, combined chromosome 7 gain and chromosome 10 loss, and TERT promoter mutation in brain tumors and their potential for the reclassification of IDHwt astrocytoma to glioblastoma. Acta Neuropathologica, 136, 793–803. https://doi.org/10.1007/s00401-018-1905-0
Abstract
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Abstract
EGFR amplification (EGFRamp), the combination of gain of chromosome 7 and loss of chromosome 10 (7+/10-), and TERT promoter mutation (pTERTmut) are alterations frequently observed in adult IDH-wild-type (IDHwt) glioblastoma (GBM). In the absence of endothelial proliferation and/or necrosis, these alterations currently are considered to serve as a surrogate for upgrading IDHwt diffuse or anaplastic astrocytoma to GBM. Here, we set out to determine the distribution of EGFRamp, 7+/10-, and pTERTmut by analyzing high-resolution copy-numbe
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- Stichel, Damian
- Ebrahimi, Azadeh
- Reuss, David
- Schrimpf, Daniel
- Ono, Takahiro
- Shirahata, Mitsuaki
- Reifenberger, Guido
- Weller, Michael
- Hänggi, Daniel
- Wick, Wolfgang
- Herold-Mende, Christel
- Westphal, Manfred
- Brandner, Sebastian
- Pfister, Stefan M
- Capper, David
- Sahm, Felix
- von Deimling, Andreas
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Stichel, D., Ebrahimi, A., Reuss, D., Schrimpf, D., Ono, T., Shirahata, M., Reifenberger, G., Weller, M., Hänggi, D., Wick, W., Herold-Mende, C., Westphal, M., Brandner, S., Pfister, S. M., Capper, D., Sahm, F., & von Deimling, A. (2018). Distribution of EGFR amplification, combined chromosome 7 gain and chromosome 10 loss, and TERT promoter mutation in brain tumors and their potential for the reclassification of IDHwt astrocytoma to glioblastoma. Acta Neuropathologica, 136, 793–803. https://doi.org/10.1007/s00401-018-1905-0
