SAXS imaging reveals optimized osseointegration properties of bioengineered oriented 3D-PLGA/aCaP scaffolds in a critical size bone defect model

Casanova, Elisa A; Rodriguez-Palomo, Adrian; Stähli, Lisa; Arnke, Kevin; Gröninger, Olivier; Generali, Melanie; Neldner, Yvonne; Tiziani, Simon; Dominguez, Ana Perez; Guizar-Sicairos, Manuel; Gao, Zirui; Appel, Christian; Nielsen, Leonard C; Georgiadis, Marios; Weber, Franz E; Stark, Wendelin; Pape, Hans-Christoph; Cinelli, Paolo; Liebi, Marianne

doi:10.1016/j.biomaterials.2022.121989

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Casanova, E. A., Rodriguez-Palomo, A., Stähli, L., Arnke, K., Gröninger, O., Generali, M., Neldner, Y., Tiziani, S., Dominguez, A. P., Guizar-Sicairos, M., Gao, Z., Appel, C., Nielsen, L. C., Georgiadis, M., Weber, F. E., Stark, W., Pape, H.-C., Cinelli, P., & Liebi, M. (2023). SAXS imaging reveals optimized osseointegration properties of bioengineered oriented 3D-PLGA/aCaP scaffolds in a critical size bone defect model. Biomaterials, 294, 121989. https://doi.org/10.1016/j.biomaterials.2022.121989

Abstract

Healing large bone defects remains challenging in orthopedic surgery and is often associated with poor outcomes and complications. A major issue with bioengineered constructs is achieving a continuous interface between host bone and graft to enhance biological processes and mechanical stability. In this study, we have developed a new bioengineering strategy to produce oriented biocompatible 3D PLGA/aCaP nanocomposites with enhanced osseointegration. Decellularized scaffolds -containing only extracellular matrix- or scaffolds seeded wi