Publication: A spatial human thymus cell atlas mapped to a continuous tissue axis
A spatial human thymus cell atlas mapped to a continuous tissue axis
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Yayon, N., Kedlian, V. R., Boehme, L., Suo, C., Wachter, B. T., Beuschel, R. T., Amsalem, O., Polanski, K., Koplev, S., Tuck, E., Dann, E., Van Hulle, J., Perera, S., Putteman, T., Predeus, A. V., Dabrowska, M., Richardson, L., Tudor, C., Kreins, A. Y., … et al. (2024). A spatial human thymus cell atlas mapped to a continuous tissue axis. Nature, 635, 708–718. https://doi.org/10.1038/s41586-024-07944-6
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T cells develop from circulating precursor cells, which enter the thymus and migrate through specialized subcompartments that support their maturation and selection$^{1}$. In humans, this process starts in early fetal development and is highly active until thymic involution in adolescence. To map the microanatomical underpinnings of this process in pre- and early postnatal stages, we established a quantitative morphological framework for the thymus—the Cortico-Medullary Axis—and used it to perform a spatially resolved analysis. Here,
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- Yayon, Nadav
- Kedlian, Veronika R
- Boehme, Lena
- Suo, Chenqu
- Wachter, Brianna T
- Beuschel, Rebecca T
- Amsalem, Oren
- Polanski, Krzysztof
- Koplev, Simon
- Tuck, Elizabeth
- Dann, Emma
- Van Hulle, Jolien
- Perera, Shani
- Putteman, Tom
- Predeus, Alexander V
- Dabrowska, Monika
- Richardson, Laura
- Tudor, Catherine
- Kreins, Alexandra Y
- Engelbert, Justin
- Stephenson, Emily
- Kleshchevnikov, Vitalii
- De Rita, Fabrizio
- Crossland, David
- Bosticardo, Marita
- Pala, Francesca
- Prigmore, Elena
- Chipampe, Nana-Jane
- Prete, Martin
- Fei, Lijiang
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Yayon, N., Kedlian, V. R., Boehme, L., Suo, C., Wachter, B. T., Beuschel, R. T., Amsalem, O., Polanski, K., Koplev, S., Tuck, E., Dann, E., Van Hulle, J., Perera, S., Putteman, T., Predeus, A. V., Dabrowska, M., Richardson, L., Tudor, C., Kreins, A. Y., … et al. (2024). A spatial human thymus cell atlas mapped to a continuous tissue axis. Nature, 635, 708–718. https://doi.org/10.1038/s41586-024-07944-6
