Publication: P2X7 receptor restrains pathogenic Tfh cell generation in systemic lupus erythematosus
P2X7 receptor restrains pathogenic Tfh cell generation in systemic lupus erythematosus
Date
Date
Date
Citations
Faliti, C. E., Gualtierotti, R., Rottoli, E., Gerosa, M., Perruzza, L., Romagnani, A., Pellegrini, G., De Ponte Conti, B., Rossi, R. L., Idzko, M., Mazza, E. M. C., Bicciato, S., Traggiai, E., Meroni, P. L., & Grassi, F. (2019). P2X7 receptor restrains pathogenic Tfh cell generation in systemic lupus erythematosus. Journal of Experimental Medicine, 216(2), 317–336. https://doi.org/10.1084/jem.20171976
Abstract
Abstract
Abstract
Altered control of T follicular helper (Tfh) cells can lead to generation of autoantibodies and autoimmune manifestations. Signaling pathways that selectively limit pathogenic responses without affecting the protective function of Tfh cells are unknown. Here we show that the ATP-gated ionotropic P2X7 receptor restricts the expansion of aberrant Tfh cells and the generation of self-reactive antibodies in experimental murine lupus, but its activity is dispensable for the expansion of antigen-specific Tfh cells during vaccination. P2X7 s
Metrics
Downloads
Views
Additional indexing
Creators (Authors)
- Faliti, Caterina E
- Gualtierotti, Roberta
- Rottoli, Elsa
- Gerosa, Maria
- Perruzza, Lisa
- Romagnani, Andrea
- Pellegrini, Giovanni
- De Ponte Conti, Benedetta
- Rossi, Riccardo L
- Idzko, Marco
- Mazza, Emilia M C
- Bicciato, Silvio
- Traggiai, Elisabetta
- Meroni, Pier Luigi
- Grassi, Fabio
Volume
Volume
Volume
Number
Number
Number
Page range/Item number
Page range/Item number
Page range/Item number
Page end
Page end
Page end
Item Type
Item Type
Item Type
In collections
Keywords
Language
Language
Language
Publication date
Publication date
Publication date
Date available
Date available
Date available
ISSN or e-ISSN
ISSN or e-ISSN
ISSN or e-ISSN
OA Status
OA Status
OA Status
Free Access at
Free Access at
Free Access at
Publisher DOI
Metrics
Downloads
Views
Citations
Faliti, C. E., Gualtierotti, R., Rottoli, E., Gerosa, M., Perruzza, L., Romagnani, A., Pellegrini, G., De Ponte Conti, B., Rossi, R. L., Idzko, M., Mazza, E. M. C., Bicciato, S., Traggiai, E., Meroni, P. L., & Grassi, F. (2019). P2X7 receptor restrains pathogenic Tfh cell generation in systemic lupus erythematosus. Journal of Experimental Medicine, 216(2), 317–336. https://doi.org/10.1084/jem.20171976
