Publication: Unique molecular and functional features of extramedullary hematopoietic stem and progenitor cell reservoirs in humans
Unique molecular and functional features of extramedullary hematopoietic stem and progenitor cell reservoirs in humans
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Mende, N., Bastos, H. P., Santoro, A., Mahbubani, K. T., Ciaurro, V., Calderbank, E. F., Quiroga LondoƱo, M., Sham, K., Mantica, G., Morishima, T., Mitchell, E., Lidonnici, M. R., Meier-Abt, F., Hayler, D., Jardine, L., Curd, A., Haniffa, M., Ferrari, G., Takizawa, H., ā¦ Laurenti, E. (2022). Unique molecular and functional features of extramedullary hematopoietic stem and progenitor cell reservoirs in humans. Blood, 139, 3387ā3401. https://doi.org/10.1182/blood.2021013450
Abstract
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Abstract
Rare hematopoietic stem and progenitor cell (HSPC) pools outside the bone marrow (BM) contribute to blood production in stress and disease but remain ill-defined. Although non-mobilized peripheral blood (PB) is routinely sampled for clinical management, the diagnosis and monitoring potential of PB HSPCs remains untapped, as no healthy PB HSPC baseline has been reported. Here we comprehensively delineate human extramedullary HSPC compartments comparing spleen, PB and mobilized PB (mPB) to BM using single-cell RNA-seq and/or functional
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Mende, N., Bastos, H. P., Santoro, A., Mahbubani, K. T., Ciaurro, V., Calderbank, E. F., Quiroga LondoƱo, M., Sham, K., Mantica, G., Morishima, T., Mitchell, E., Lidonnici, M. R., Meier-Abt, F., Hayler, D., Jardine, L., Curd, A., Haniffa, M., Ferrari, G., Takizawa, H., ā¦ Laurenti, E. (2022). Unique molecular and functional features of extramedullary hematopoietic stem and progenitor cell reservoirs in humans. Blood, 139, 3387ā3401. https://doi.org/10.1182/blood.2021013450
