Publication: Modulation of fracture healing by senescence-associated secretory phenotype (SASP): a narrative review of the current literature
Modulation of fracture healing by senescence-associated secretory phenotype (SASP): a narrative review of the current literature
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Zhao, S., Qiao, Z., Pfeifer, R., Pape, H.-C., Mao, K., Tang, H., Meng, B., Chen, S., & Liu, H. (2024). Modulation of fracture healing by senescence-associated secretory phenotype (SASP): a narrative review of the current literature. European Journal of Medical Research, 29, 38. https://doi.org/10.1186/s40001-023-01604-7
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Abstract
The senescence-associated secretory phenotype (SASP) is a generic term for the secretion of cytokines, such as pro-inflammatory factors and proteases. It is a crucial feature of senescent cells. SASP factors induce tissue remodeling and immune cell recruitment. Previous studies have focused on the beneficial role of SASP during embryonic development, wound healing, tissue healing in general, immunoregulation properties, and cancer. However, some recent studies have identified several negative effects of SASP on fracture healing. Senol
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- Zhao, Shangkun
- Qiao, Zhi
- Pfeifer, Roman
- Pape, Hans-Christoph
- Mao, Keya
- Tang, Hai
- Meng, Bin
- Chen, Songfeng
- Liu, Hongjian
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Zhao, S., Qiao, Z., Pfeifer, R., Pape, H.-C., Mao, K., Tang, H., Meng, B., Chen, S., & Liu, H. (2024). Modulation of fracture healing by senescence-associated secretory phenotype (SASP): a narrative review of the current literature. European Journal of Medical Research, 29, 38. https://doi.org/10.1186/s40001-023-01604-7
