Publication: From in vitro towards in situ: structure-based investigation of ABC exporters by electron paramagnetic resonance spectroscopy
From in vitro towards in situ: structure-based investigation of ABC exporters by electron paramagnetic resonance spectroscopy
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Bordignon, E., Seeger, M. A., Galazzo, L., & Meier, G. (2020). From in vitro towards in situ: structure-based investigation of ABC exporters by electron paramagnetic resonance spectroscopy. FEBS Letters, 594, 3839–3856. https://doi.org/10.1002/1873-3468.14004
Abstract
Abstract
Abstract
ATP-binding cassette (ABC) exporters have been studied now for more than four decades, and recent structural investigation has produced a large number of protein database entries. Yet, important questions about how ABC exporters function at the molecular level remain debated, such as which are the molecular recognition hotspots and the allosteric couplings dynamically regulating the communication between the catalytic cycle and the export of substrates. This conundrum mainly arises from technical limitations confining all research to
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- Bordignon, Enrica
- Seeger, Markus A
- Galazzo, Laura
- Meier, Gianmarco
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Citations
Bordignon, E., Seeger, M. A., Galazzo, L., & Meier, G. (2020). From in vitro towards in situ: structure-based investigation of ABC exporters by electron paramagnetic resonance spectroscopy. FEBS Letters, 594, 3839–3856. https://doi.org/10.1002/1873-3468.14004
