Publication: Myelin is dependent on the Charcot-Marie-Tooth Type 4H disease culprit protein FRABIN/FGD4 in Schwann cells
Myelin is dependent on the Charcot-Marie-Tooth Type 4H disease culprit protein FRABIN/FGD4 in Schwann cells
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Horn, M., Baumann, R., Pereira, J. A., Sidiropoulos, P. N. M., Somandin, C., Welzl, H., Stendel, C., Lühmann, T., Wessig, C., Toyka, K. V., Relvas, J. B., Senderek, J., & Suter, U. (2012). Myelin is dependent on the Charcot-Marie-Tooth Type 4H disease culprit protein FRABIN/FGD4 in Schwann cells. Brain : A Journal of Neurology, 135(Pt 12), 3567–3683. https://doi.org/10.1093/brain/aws275
Abstract
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Abstract
Studying the function and malfunction of genes and proteins associated with inherited forms of peripheral neuropathies has provided multiple clues to our understanding of myelinated nerves in health and disease. Here, we have generated a mouse model for the peripheral neuropathy Charcot-Marie-Tooth disease type 4H by constitutively disrupting the mouse orthologue of the suspected culprit gene FGD4 that encodes the small RhoGTPase Cdc42-guanine nucleotide exchange factor Frabin. Lack of Frabin/Fgd4 causes dysmyelination in mice in earl
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Creators (Authors)
- Horn, Michael
- Baumann, Reto
- Pereira, Jorge A
- Sidiropoulos, Páris N M
- Somandin, Christian
- Welzl, Hans
- Stendel, Claudia
- Lühmann, Tessa
- Wessig, Carsten
- Toyka, Klaus V
- Relvas, João B
- Senderek, Jan
- Suter, Ueli
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Citations
Horn, M., Baumann, R., Pereira, J. A., Sidiropoulos, P. N. M., Somandin, C., Welzl, H., Stendel, C., Lühmann, T., Wessig, C., Toyka, K. V., Relvas, J. B., Senderek, J., & Suter, U. (2012). Myelin is dependent on the Charcot-Marie-Tooth Type 4H disease culprit protein FRABIN/FGD4 in Schwann cells. Brain : A Journal of Neurology, 135(Pt 12), 3567–3683. https://doi.org/10.1093/brain/aws275
