Publication: Antimicrobial peptide gene expression in medication-related osteonecrosis of the jaw
Antimicrobial peptide gene expression in medication-related osteonecrosis of the jaw
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Thiel, Y. (2021). Antimicrobial peptide gene expression in medication-related osteonecrosis of the jaw. (Dissertation, University of Zurich) https://doi.org/10.5167/uzh-213925
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Bisphosphonates and denosumab are commonly used antiresorptive therapies in patients with bone metastasis and osteoporosis. Medication-related osteonecrosis of the jaw (MRONJ) is a serious side effect of these drugs, and infection has been recognized as a contributing factor. Current therapeutic options for MRONJ show limited effectiveness, therefore necessitating novel treatment strategies. Bisphosphonates have recently been reported to induce the expression of antimicrobial peptides (AMPs), an inherent component of the immune system
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Thiel, Y. (2021). Antimicrobial peptide gene expression in medication-related osteonecrosis of the jaw. (Dissertation, University of Zurich) https://doi.org/10.5167/uzh-213925
