Publication: Polyamines and eIF5A Hypusination Modulate Mitochondrial Respiration and Macrophage Activation
Polyamines and eIF5A Hypusination Modulate Mitochondrial Respiration and Macrophage Activation
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Puleston, D. J., Buck, M. D., Klein Geltink, R. I., et al, Pällman, N., & Balabanov, S. (2019). Polyamines and eIF5A Hypusination Modulate Mitochondrial Respiration and Macrophage Activation. Cell Metabolism, 30(2), 352-363.e8. https://doi.org/10.1016/j.cmet.2019.05.003
Abstract
Abstract
Abstract
How cells adapt metabolism to meet demands is an active area of interest across biology. Among a broad range of functions, the polyamine spermidine is needed to hypusinate the translation factor eukaryotic initiation factor 5A (eIF5A). We show here that hypusinated eIF5A (eIF5A$^{H}$) promotes the efficient expression of a subset of mitochondrial proteins involved in the TCA cycle and oxidative phosphorylation (OXPHOS). Several of these proteins have mitochondrial targeting sequences (MTSs) that in part confer an increased dependency
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Creators (Authors)
- Puleston, Daniel J
- Buck, Michael D
- Klein Geltink, Ramon I
- Pällman, Nora
- Balabanov, Stefan
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Citations
Puleston, D. J., Buck, M. D., Klein Geltink, R. I., et al, Pällman, N., & Balabanov, S. (2019). Polyamines and eIF5A Hypusination Modulate Mitochondrial Respiration and Macrophage Activation. Cell Metabolism, 30(2), 352-363.e8. https://doi.org/10.1016/j.cmet.2019.05.003
