Hemorrhagic shock drives glycocalyx, barrier and organ dysfunction early after polytrauma

Halbgebauer, Rebecca; Braun, Christian K; Denk, Stephanie; Mayer, Benjamin; Cinelli, Paolo; Radermacher, Peter; Wanner, Guido A; Simmen, Hans-Peter; Gebhard, Florian; Rittirsch, Daniel; Huber-Lang, Markus

doi:10.5167/uzh-142833

Citations

Citation copied

Halbgebauer, R., Braun, C. K., Denk, S., Mayer, B., Cinelli, P., Radermacher, P., Wanner, G. A., Simmen, H.-P., Gebhard, F., Rittirsch, D., & Huber-Lang, M. (2017). Hemorrhagic shock drives glycocalyx, barrier and organ dysfunction early after polytrauma. Journal of Critical Care, 44, 229–237. https://doi.org/10.1016/j.jcrc.2017.11.025

Abstract

Polytrauma (PT) is frequently associated with hemorrhagic shock (HS), which increases morbidity and mortality. Although various aspects of HS have been addressed in PT patients, the impact of an additional HS is largely unknown regarding the development of multiple organ dysfunction associated with disturbed glycocalyx and barrier function early after trauma. A prospective, longitudinal, mono-centered, observational study enrolling severely injured patients (Injury Severity Score, ISS=38.1±2.6) served for an in-depth analysis of blood