Trifunctional (99m)Tc based radiopharmaceuticals: metal-mediated conjugation of a peptide with a nucleus targeting intercalator

Abstract

The development of molecular imaging agents with multiple functions has become a major trend in radiopharmaceutical chemistry. We present herein the syntheses of trifunctional compounds, combining an acridine orange (AO) based intercalator with a GRP receptor specific bombesin like peptide (BBN). Metal-mediated conjugation of these two functions via the 2 + 1] approach to the third function, the M(CO)(3)](+) (M = (99m)Tc, Re) moiety, yielded the final trifunctional molecules. The strongly fluorescent acridine orange, a nuclear targeti Show more