Publication: Xeroderma pigmentosum group C sensor: unprecedented recognition strategy and tight spatiotemporal regulation
Xeroderma pigmentosum group C sensor: unprecedented recognition strategy and tight spatiotemporal regulation
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Puumalainen, M.-R., Rüthemann, P., Min, J.-H., & Naegeli, H. (2016). Xeroderma pigmentosum group C sensor: unprecedented recognition strategy and tight spatiotemporal regulation. Cellular and Molecular Life Sciences, 73(3), 547–566. https://doi.org/10.1007/s00018-015-2075-z
Abstract
Abstract
Abstract
The cellular defense system known as global-genome nucleotide excision repair (GG-NER) safeguards genome stability by eliminating a plethora of structurally unrelated DNA adducts inflicted by chemical carcinogens, ultraviolet (UV) radiation or endogenous metabolic by-products. Xeroderma pigmentosum group C (XPC) protein provides the promiscuous damage sensor that initiates this versatile NER reaction through the sequential recruitment of DNA helicases and endonucleases, which in turn recognize and excise insulting base adducts. As a D
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Creators (Authors)
- Puumalainen, Marjo-Riitta
- Rüthemann, Peter
- Min, Jun-Hyun
- Naegeli, Hanspeter
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Citations
Puumalainen, M.-R., Rüthemann, P., Min, J.-H., & Naegeli, H. (2016). Xeroderma pigmentosum group C sensor: unprecedented recognition strategy and tight spatiotemporal regulation. Cellular and Molecular Life Sciences, 73(3), 547–566. https://doi.org/10.1007/s00018-015-2075-z
