Publication: The transcription factor HIF-1α mediates plasticity of NKp46+ innate lymphoid cells in the gut
The transcription factor HIF-1α mediates plasticity of NKp46+ innate lymphoid cells in the gut
Date
Date
Date
Citations
Krzywinska, E., Sobecki, M., Nagarajan, S., Zacharjasz, J., Tambuwala, M. M., Pelletier, A., Cummins, E., Gotthardt, D., Fandrey, J., Kerdiles, Y. M., Peyssonnaux, C., Taylor, C. T., Sexl, V., & Stockmann, C. (2022). The transcription factor HIF-1α mediates plasticity of NKp46+ innate lymphoid cells in the gut. Journal of Experimental Medicine, 219(2), e20210909. https://doi.org/10.1084/jem.20210909
Abstract
Abstract
Abstract
Gut innate lymphoid cells (ILCs) show remarkable phenotypic diversity, yet microenvironmental factors that drive this plasticity are incompletely understood. The balance between NKp46+, IL-22-producing, group 3 ILCs (ILC3s) and interferon (IFN)-γ-producing group 1 ILCs (ILC1s) contributes to gut homeostasis. The gut mucosa is characterized by physiological hypoxia, and adaptation to low oxygen is mediated by hypoxia-inducible transcription factors (HIFs). However, the impact of HIFs on ILC phenotype and gut homeostasis is not well und
Metrics
Downloads
Views
Additional indexing
Creators (Authors)
Volume
Volume
Volume
Number
Number
Number
Page range/Item number
Page range/Item number
Page range/Item number
Item Type
Item Type
Item Type
In collections
Dewey Decimal Classifikation
Dewey Decimal Classifikation
Dewey Decimal Classifikation
Language
Language
Language
Publication date
Publication date
Publication date
Date available
Date available
Date available
ISSN or e-ISSN
ISSN or e-ISSN
ISSN or e-ISSN
OA Status
OA Status
OA Status
Free Access at
Free Access at
Free Access at
Publisher DOI
Metrics
Downloads
Views
Citations
Krzywinska, E., Sobecki, M., Nagarajan, S., Zacharjasz, J., Tambuwala, M. M., Pelletier, A., Cummins, E., Gotthardt, D., Fandrey, J., Kerdiles, Y. M., Peyssonnaux, C., Taylor, C. T., Sexl, V., & Stockmann, C. (2022). The transcription factor HIF-1α mediates plasticity of NKp46+ innate lymphoid cells in the gut. Journal of Experimental Medicine, 219(2), e20210909. https://doi.org/10.1084/jem.20210909
