Publication: Epigenetic mechanisms in schizophrenia and other psychotic disorders: a systematic review of empirical human findings
Epigenetic mechanisms in schizophrenia and other psychotic disorders: a systematic review of empirical human findings
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Smigielski, L., Jagannath, V., Rössler, W., Walitza, S., & Grünblatt, E. (2020). Epigenetic mechanisms in schizophrenia and other psychotic disorders: a systematic review of empirical human findings. Molecular Psychiatry, 25(8), 1718–1748. https://doi.org/10.1038/s41380-019-0601-3
Abstract
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Abstract
Schizophrenia and other psychotic disorders are highly debilitating psychiatric conditions that lack a clear etiology and exhibit polygenic inheritance underlain by pleiotropic genes. The prevailing explanation points to the interplay between predisposing genes and environmental exposure. Accumulated evidence suggests that epigenetic regulation of the genome may mediate dynamic gene–environment interactions at the molecular level by modulating the expression of psychiatric phenotypes through transcription factors. This systematic revi
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- Smigielski, Lukasz
- Jagannath, Vinita
- Rössler, Wulf
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Citations
Smigielski, L., Jagannath, V., Rössler, W., Walitza, S., & Grünblatt, E. (2020). Epigenetic mechanisms in schizophrenia and other psychotic disorders: a systematic review of empirical human findings. Molecular Psychiatry, 25(8), 1718–1748. https://doi.org/10.1038/s41380-019-0601-3
