Publication: Mouse psychosocial stress reduces motivation and cognitive function in operant reward tests: A model for reward pathology with effects of agomelatine
Mouse psychosocial stress reduces motivation and cognitive function in operant reward tests: A model for reward pathology with effects of agomelatine
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Bergamini, G., Cathomas, F., Auer, S., Sigrist, H., Seifritz, E., Patterson, M., Gabriel, C., & Pryce, C. R. (2016). Mouse psychosocial stress reduces motivation and cognitive function in operant reward tests: A model for reward pathology with effects of agomelatine. European Neuropsychopharmacology, 26(9), 1448–1464. https://doi.org/10.1016/j.euroneuro.2016.06.009
Abstract
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A major domain of depression is decreased motivation for reward. Translational automated tests can be applied in humans and animals to study operant reward behaviour, aetio-pathophysiology underlying deficits therein, and effects of antidepressant treatment. Three inter-related experiments were conducted to investigate depression-relevant effects of chronic psychosocial stress on operant behaviour in mice. (A) Non-manipulated mice were trained on a complex reversal learning (CRL) test with sucrose reinforcement; relative to vehicle (V
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- Bergamini, Giorgio
- Cathomas, Flurin
- Auer, Sandra
- Sigrist, Hannes
- Seifritz, Erich
- Patterson, Michael
- Gabriel, Cecilia
- Pryce, Christopher R
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Bergamini, G., Cathomas, F., Auer, S., Sigrist, H., Seifritz, E., Patterson, M., Gabriel, C., & Pryce, C. R. (2016). Mouse psychosocial stress reduces motivation and cognitive function in operant reward tests: A model for reward pathology with effects of agomelatine. European Neuropsychopharmacology, 26(9), 1448–1464. https://doi.org/10.1016/j.euroneuro.2016.06.009
