Publication: Local Gurken signaling and dynamic MAPK activation during Drosophila oogenesis
Local Gurken signaling and dynamic MAPK activation during Drosophila oogenesis
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Peri, F., Bökel, C., & Roth, S. (1999). Local Gurken signaling and dynamic MAPK activation during Drosophila oogenesis. Mechanisms of Development, 81(1–2), 75–88. https://doi.org/10.1016/s0925-4773(98)00228-7
Abstract
Abstract
Abstract
During Drosophila melanogaster oogenesis Gurken, a TGF-α like protein localized close to the oocyte nucleus, activates the MAPK cascade via the Drosophila EGF receptor (DER). Activation of this pathway induces different cell fates in the overlying follicular epithelium, specifying the two dorsolaterally positioned respiratory appendages and the dorsalmost cells separating them. Signal-associated internalization of Gurken protein into follicle cells demonstrates that the Gurken signal is spatially restricted and of constant intensity d
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- Peri, Francesca
- Bökel, Christian
- Roth, Siegfried
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Peri, F., Bökel, C., & Roth, S. (1999). Local Gurken signaling and dynamic MAPK activation during Drosophila oogenesis. Mechanisms of Development, 81(1–2), 75–88. https://doi.org/10.1016/s0925-4773(98)00228-7
