Publication: Transmembrane regions of bovine herpesvirus 1-encoded UL49.5 and glycoprotein M regulate complex maturation and ER-Golgi trafficking
Transmembrane regions of bovine herpesvirus 1-encoded UL49.5 and glycoprotein M regulate complex maturation and ER-Golgi trafficking
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Graul, M., Kisielnicka, E., Rychłowski, M., Verweij, M. C., Tobler, K., Ackermann, M., Wiertz, E. J. H. J., Bieńkowska-Szewczyk, K., & Lipińska, A. D. (2019). Transmembrane regions of bovine herpesvirus 1-encoded UL49.5 and glycoprotein M regulate complex maturation and ER-Golgi trafficking. Journal of General Virology, 100(3), 497–510. https://doi.org/10.1099/jgv.0.001224
Abstract
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Abstract
Bovine herpesvirus 1 (BoHV-1)-encoded UL49.5 (a homologue of herpesvirus glycoprotein N) can combine different functions, regulated by complex formation with viral glycoprotein M (gM). We aimed to identify the mechanisms governing the immunomodulatory activity of BoHV-1 UL49.5. In this study, we addressed the impact of gM/UL49.5-specific regions on heterodimer formation, folding and trafficking from the endoplasmic reticulum (ER) to the trans-Golgi network (TGN) - events previously found to be responsible for abrogation of the UL49.5-
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Creators (Authors)
- Graul, Małgorzata
- Kisielnicka, Edyta
- Rychłowski, Michał
- Verweij, Marieke C
- Tobler, Kurt
- Ackermann, Mathias
- Wiertz, Emmanuel J H J
- Bieńkowska-Szewczyk, Krystyna
- Lipińska, Andrea D
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Graul, M., Kisielnicka, E., Rychłowski, M., Verweij, M. C., Tobler, K., Ackermann, M., Wiertz, E. J. H. J., Bieńkowska-Szewczyk, K., & Lipińska, A. D. (2019). Transmembrane regions of bovine herpesvirus 1-encoded UL49.5 and glycoprotein M regulate complex maturation and ER-Golgi trafficking. Journal of General Virology, 100(3), 497–510. https://doi.org/10.1099/jgv.0.001224
