Publication: The RNA-binding protein Musashi controls axon compartment-specific synaptic connectivity through ptp69D mRNA poly(A)-tailing
The RNA-binding protein Musashi controls axon compartment-specific synaptic connectivity through ptp69D mRNA poly(A)-tailing
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Landínez-Macías, M., Qi, W., Bratus-Neuenschwander, A., Müller, M., & Urwyler, O. (2021). The RNA-binding protein Musashi controls axon compartment-specific synaptic connectivity through ptp69D mRNA poly(A)-tailing. Cell Reports, 36(11), 109713. https://doi.org/10.1016/j.celrep.2021.109713
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Synaptic targeting with subcellular specificity is essential for neural circuit assembly. Developing neurons use mechanisms to curb promiscuous synaptic connections and to direct synapse formation to defined subcellular compartments. How this selectivity is achieved molecularly remains enigmatic. Here, we discover a link between mRNA poly(A)-tailing and axon collateral branch-specific synaptic connectivity within the CNS. We reveal that the RNA-binding protein Musashi binds to the mRNA encoding the receptor protein tyrosine phosphatas
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Landínez-Macías, M., Qi, W., Bratus-Neuenschwander, A., Müller, M., & Urwyler, O. (2021). The RNA-binding protein Musashi controls axon compartment-specific synaptic connectivity through ptp69D mRNA poly(A)-tailing. Cell Reports, 36(11), 109713. https://doi.org/10.1016/j.celrep.2021.109713
