Publication: Dynamics of transcriptional programs and chromatin accessibility in mouse spermatogonial cells from early postnatal to adult life
Dynamics of transcriptional programs and chromatin accessibility in mouse spermatogonial cells from early postnatal to adult life
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Lazar-Contes, I., Arzate-Mejia, R. G., Tanwar, D. K., Steg, L. C., Uzel, K., Feudjio, O. U., Crespo, M., Germain, P.-L., & Mansuy, I. M. (2025). Dynamics of transcriptional programs and chromatin accessibility in mouse spermatogonial cells from early postnatal to adult life. ELife, 12, RP91528. https://doi.org/10.7554/eLife.91528.3
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In mammals, spermatogonial cells (SPGs) are undifferentiated male germ cells in testis that are quiescent until birth and then self-renew and differentiate to produce spermatogenic cells and functional sperm from early postnatal life throughout adulthood. The transcriptome of SPGs is highly dynamic and timely regulated during postnatal development. We examined if such dynamics involves changes in chromatin organization by profiling the transcriptome and chromatin accessibility of SPGs from early postnatal stages to adulthood in mice u
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Lazar-Contes, I., Arzate-Mejia, R. G., Tanwar, D. K., Steg, L. C., Uzel, K., Feudjio, O. U., Crespo, M., Germain, P.-L., & Mansuy, I. M. (2025). Dynamics of transcriptional programs and chromatin accessibility in mouse spermatogonial cells from early postnatal to adult life. ELife, 12, RP91528. https://doi.org/10.7554/eLife.91528.3