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Dynamics of transcriptional programs and chromatin accessibility in mouse spermatogonial cells from early postnatal to adult life

Date

Date

Date
2025
Journal Article
Published version

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Lazar-Contes, I., Arzate-Mejia, R. G., Tanwar, D. K., Steg, L. C., Uzel, K., Feudjio, O. U., Crespo, M., Germain, P.-L., & Mansuy, I. M. (2025). Dynamics of transcriptional programs and chromatin accessibility in mouse spermatogonial cells from early postnatal to adult life. ELife, 12, RP91528. https://doi.org/10.7554/eLife.91528.3

Abstract

Abstract

Abstract

In mammals, spermatogonial cells (SPGs) are undifferentiated male germ cells in testis that are quiescent until birth and then self-renew and differentiate to produce spermatogenic cells and functional sperm from early postnatal life throughout adulthood. The transcriptome of SPGs is highly dynamic and timely regulated during postnatal development. We examined if such dynamics involves changes in chromatin organization by profiling the transcriptome and chromatin accessibility of SPGs from early postnatal stages to adulthood in mice u

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Creators (Authors)

  • Lazar-Contes, Irina
  • Arzate-Mejia, Rodrigo G
  • Tanwar, Deepak K
  • Steg, Leonard C
  • Uzel, Kerem
  • Feudjio, Olivier Ulrich
  • Crespo, Marion
  • Germain, Pierre-Luc
  • Mansuy, Isabelle M

Journal/Series Title

Journal/Series Title

Journal/Series Title

Volume

Volume

Volume
12

Page range/Item number

Page range/Item number

Page range/Item number
RP91528

Item Type

Item Type

Item Type
Journal Article

Dewey Decimal Classifikation

Dewey Decimal Classifikation

Dewey Decimal Classifikation

Language

Language

Language
English

Publication date

Publication date

Publication date
2025-04-25

Date available

Date available

Date available
2024-01-16

Publisher

Publisher

Publisher
eLife Sciences Publications Ltd.

ISSN or e-ISSN

ISSN or e-ISSN

ISSN or e-ISSN
2050-084X

OA Status

OA Status

OA Status
Gold

Free Access at

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Lazar-Contes, I., Arzate-Mejia, R. G., Tanwar, D. K., Steg, L. C., Uzel, K., Feudjio, O. U., Crespo, M., Germain, P.-L., & Mansuy, I. M. (2025). Dynamics of transcriptional programs and chromatin accessibility in mouse spermatogonial cells from early postnatal to adult life. ELife, 12, RP91528. https://doi.org/10.7554/eLife.91528.3

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