Publication: A Comprehensive Drosophila melanogaster Transcription Factor Interactome
A Comprehensive Drosophila melanogaster Transcription Factor Interactome
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Shokri, L., Inukai, S., Hafner, A., Weinand, K., Hens, K., Vedenko, A., Gisselbrecht, S. S., Dainese, R., Bischof, J., Furger, E., Feuz, J.-D., Basler, K., Deplancke, B., & Bulyk, M. L. (2019). A Comprehensive Drosophila melanogaster Transcription Factor Interactome. Cell Reports, 27(3), 955-970.e7. https://doi.org/10.1016/j.celrep.2019.03.071
Abstract
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Abstract
Combinatorial interactions among transcription factors (TFs) play essential roles in generating gene expression specificity and diversity in metazoans. Using yeast 2-hybrid (Y2H) assays on nearly all sequence-specific Drosophila TFs, we identified 1,983 protein-protein interactions (PPIs), more than doubling the number of currently known PPIs among Drosophila TFs. For quality assessment, we validated a subset of our interactions using MITOMI and bimolecular fluorescence complementation assays. We combined our interactome with prior PP
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- Shokri, Leila
- Inukai, Sachi
- Hafner, Antonina
- Weinand, Kathryn
- Hens, Korneel
- Vedenko, Anastasia
- Gisselbrecht, Stephen S
- Dainese, Riccardo
- Bischof, Johannes
- Furger, Edy
- Feuz, Jean-Daniel
- Deplancke, Bart
- Bulyk, Martha L
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Shokri, L., Inukai, S., Hafner, A., Weinand, K., Hens, K., Vedenko, A., Gisselbrecht, S. S., Dainese, R., Bischof, J., Furger, E., Feuz, J.-D., Basler, K., Deplancke, B., & Bulyk, M. L. (2019). A Comprehensive Drosophila melanogaster Transcription Factor Interactome. Cell Reports, 27(3), 955-970.e7. https://doi.org/10.1016/j.celrep.2019.03.071
