Publication: The First Total Synthesis of the Peptaibol Hypomurocin A1 and Its Conformation Analysis: an Application of the 'Azirine/Oxazolone Method'
The First Total Synthesis of the Peptaibol Hypomurocin A1 and Its Conformation Analysis: an Application of the 'Azirine/Oxazolone Method'
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Pradeille, N., Zerbe, O., Möhle, K., Linden, A., & Heimgartner, H. (2005). The First Total Synthesis of the Peptaibol Hypomurocin A1 and Its Conformation Analysis: an Application of the “Azirine/Oxazolone Method.” Chemistry & Biodiversity, 2, 1127–1152. https://doi.org/10.1002/cbdv.200590084
Abstract
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Abstract
The first total synthesis of Hypomurocin A1 (HM A1) in solution phase is described. As members of the peptaibol family, hypomurocins are constituted by two groups of peptides: six undecapeptides (undecamers) in the HM A group and six octadecapeptides (18-mers) in the HM B group. The synthesis presented has been successfully achieved by the 'azirine/oxazolone method' to introduce the two Aib-Pro sequences included in this undecapeptaibol in one step with methyl 2,2-dimethyl-2H-azirine-3-prolinate as the building block. The coupling rea
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- Pradeille, Nicolas
- Zerbe, Oliver
- Möhle, Kerstin
- Heimgartner, Heinz
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Pradeille, N., Zerbe, O., Möhle, K., Linden, A., & Heimgartner, H. (2005). The First Total Synthesis of the Peptaibol Hypomurocin A1 and Its Conformation Analysis: an Application of the “Azirine/Oxazolone Method.” Chemistry & Biodiversity, 2, 1127–1152. https://doi.org/10.1002/cbdv.200590084
