Serological Assays for Alveolar and Cystic Echinococcosis—A Comparative Multi-Test Study in Switzerland and Kyrgyzstan

Kronenberg, Philipp Andreas; Deibel, Ansgar; Gottstein, Bruno; Grimm, Felix; Müllhaupt, Beat; Meyer zu Schwabedissen, Cordula; Aitbaev, Sezdbek; Omorov, Rakhatbek A; Abdykerimov, Kubanychbek K; Minbaeva, Gulnara; Usubalieva, Jumagul; Siles-Lucas, Mar; Pepe, Paola; Rinaldi, Laura; Spiliotis, Markus; Wang, Junhua; Müller, Norbert; Torgerson, Paul R; Deplazes, Peter

doi:10.5167/uzh-220411

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Kronenberg, P. A., Deibel, A., Gottstein, B., Grimm, F., Müllhaupt, B., Meyer zu Schwabedissen, C., Aitbaev, S., Omorov, R. A., Abdykerimov, K. K., Minbaeva, G., Usubalieva, J., Siles-Lucas, M., Pepe, P., Rinaldi, L., Spiliotis, M., Wang, J., Müller, N., Torgerson, P. R., & Deplazes, P. (2022). Serological Assays for Alveolar and Cystic Echinococcosis—A Comparative Multi-Test Study in Switzerland and Kyrgyzstan. Pathogens, 11(5), 518. https://doi.org/10.3390/pathogens11050518

Abstract

Both alveolar (AE) and cystic echinococcosis (CE) are lacking pathognomonic clinical signs; consequently imaging technologies and serology remain the main pillars for diagnosis. The present study included 100 confirmed treatment-naïve AE and 64 CE patients that were diagnosed in Switzerland or Kyrgyzstan. Overall, 10 native Echinococcus spp. antigens, 3 recombinant antigens, and 4 commercial assays were comparatively evaluated. All native E. multilocularis antigens were produced in duplicates with a European and a Kyrgyz isolate and s