Publication: Distinguishable DNA methylation defines a cardiac-specific epigenetic clock
Distinguishable DNA methylation defines a cardiac-specific epigenetic clock
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Mongelli, A., Panunzi, S., Nesta, M., Gottardi Zamperla, M., Atlante, S., Barbi, V., Mongiardini, V., Ferraro, F., De Martino, S., Cis, L., Re, A., Maltese, S., Bachetti, T., La Rovere, M. T., Martelli, F., Pesce, M., Nanni, S., Massetti, M., Pontecorvi, A., … Gaetano, C. (2023). Distinguishable DNA methylation defines a cardiac-specific epigenetic clock. Clinical Epigenetics, 15(1), 53. https://doi.org/10.1186/s13148-023-01467-z
Abstract
Abstract
Abstract
BACKGROUND
The present study investigates whether epigenetic differences emerge in the heart of patients undergoing cardiac surgery for an aortic valvular replacement (AVR) or coronary artery bypass graft (CABG). An algorithm is also established to determine how the pathophysiological condition might influence the human biological cardiac age.
RESULTS
Blood samples and cardiac auricles were collected from patients who underwent cardiac procedures: 94 AVR and 289 CABG. The CpGs from three independent blood-derived biological clocks
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Creators (Authors)
- Mongelli, A
- Panunzi, S
- Nesta, M
- Gottardi Zamperla, M
- Atlante, S
- Barbi, V
- Mongiardini, V
- Ferraro, F
- De Martino, S
- Cis, L
- Re, A
- Maltese, S
- Bachetti, T
- La Rovere, M T
- Martelli, F
- Pesce, M
- Nanni, S
- Massetti, M
- Pontecorvi, A
- Farsetti, A
- Gaetano, C
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Mongelli, A., Panunzi, S., Nesta, M., Gottardi Zamperla, M., Atlante, S., Barbi, V., Mongiardini, V., Ferraro, F., De Martino, S., Cis, L., Re, A., Maltese, S., Bachetti, T., La Rovere, M. T., Martelli, F., Pesce, M., Nanni, S., Massetti, M., Pontecorvi, A., … Gaetano, C. (2023). Distinguishable DNA methylation defines a cardiac-specific epigenetic clock. Clinical Epigenetics, 15(1), 53. https://doi.org/10.1186/s13148-023-01467-z
