Risk adaptive planning with biology-based constraints may lead to higher tumor control probability in tumors of the canine brain: A planning study

Radonic, Stephan; Schneider, Uwe; Besserer, Jürgen; Meier, Valeria S; Rohrer Bley, Carla

doi:10.1016/j.ejmp.2024.103317

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Radonic, S., Schneider, U., Besserer, J., Meier, V. S., & Rohrer Bley, C. (2024). Risk adaptive planning with biology-based constraints may lead to higher tumor control probability in tumors of the canine brain: A planning study. Physica Medica, 119, 103317. https://doi.org/10.1016/j.ejmp.2024.103317

Abstract

Background: Classical radiation protocols are guided by physical dose delivered homogeneously over the target. Protocols are chosen to keep normal tissue complication probability (NTCP) at an acceptable level. Organs at risk (OAR) adjacent to the target volume could lead to underdosage of the tumor and a decrease of tumor control probability (TCP). The intent of our study was to explore a biology-based dose escalation: by keeping NTCP for OAR constant, radiation dose was to be maximized, allowing to result in heterogeneous dose distri