Publication: Live visualization of herpes simplex virus type 1 compartment dynamics
Live visualization of herpes simplex virus type 1 compartment dynamics
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De Oliveira, A. P., Glauser, D. L., Laimbacher, A. S., Strasser, R., Schraner, E. M., Wild, P., Ziegler, U., Breakefield, X. O., Ackermann, M., & Fraefel, C. (2008). Live visualization of herpes simplex virus type 1 compartment dynamics. Journal of Virology, 82, 4974–4990. https://doi.org/10.1128/JVI.02431-07
Abstract
Abstract
Abstract
We have constructed a recombinant herpes simplex virus type 1 (HSV-1) that simultaneously encodes selected structural proteins from all three virion compartments-capsid, tegument, and envelope-fused with autofluorescent proteins. This triple-fluorescent recombinant, rHSV-RYC, was replication competent, albeit with delayed kinetics, incorporated the fusion proteins into all three virion compartments, and was comparable to wild-type HSV-1 at the ultrastructural level. The VP26 capsid fusion protein (monomeric red fluorescent protein [mR
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Creators (Authors)
- De Oliveira, A P
- Glauser, D L
- Laimbacher, A S
- Strasser, R
- Schraner, E M
- Wild, P
- Ziegler, U
- Breakefield, X O
- Ackermann, M
- Fraefel, C
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Citations
De Oliveira, A. P., Glauser, D. L., Laimbacher, A. S., Strasser, R., Schraner, E. M., Wild, P., Ziegler, U., Breakefield, X. O., Ackermann, M., & Fraefel, C. (2008). Live visualization of herpes simplex virus type 1 compartment dynamics. Journal of Virology, 82, 4974–4990. https://doi.org/10.1128/JVI.02431-07
