Publication: The effect of O6-alkylguanine-DNA alkyltransferase and mismatch repair activities on the sensitivity of human melanoma cells to temozolomide, 1,3-bis(2-chloroethyl)1-nitrosourea, and cisplatin
The effect of O6-alkylguanine-DNA alkyltransferase and mismatch repair activities on the sensitivity of human melanoma cells to temozolomide, 1,3-bis(2-chloroethyl)1-nitrosourea, and cisplatin
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Pepponi, R., Marra, G., Fuggetta, M. P., Falcinelli, S., Pagani, E., Bonmassar, E., Jiricny, J., & D’Atri, S. (2003). The effect of O6-alkylguanine-DNA alkyltransferase and mismatch repair activities on the sensitivity of human melanoma cells to temozolomide, 1,3-bis(2-chloroethyl)1-nitrosourea, and cisplatin. Journal of Pharmacology and Experimental Therapeutics, 304(2), 661–668. https://doi.org/10.1124/jpet.102.043950
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The prognosis of advanced melanoma is generally poor, because this tumor commonly exhibits intrinsic or acquired resistance to chemotherapy. In an attempt to identify the underlying causes of this resistance, we studied the roles played by the DNA repair enzyme O(6)-alkylguanine-DNA alkyltransferase (OGAT) and the mismatch repair (MMR) system in the sensitivity of melanoma cells to temozolomide (TMZ), 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU), or cis-diamminedichloroplatinum(II) (CDDP). To this end, OGAT levels and MMR efficiency of
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- Pepponi, R
- Marra, Giancarlo
- Fuggetta, M P
- Falcinelli, S
- Pagani, E
- Bonmassar, E
- Jiricny, J
- D'Atri, S
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Pepponi, R., Marra, G., Fuggetta, M. P., Falcinelli, S., Pagani, E., Bonmassar, E., Jiricny, J., & D’Atri, S. (2003). The effect of O6-alkylguanine-DNA alkyltransferase and mismatch repair activities on the sensitivity of human melanoma cells to temozolomide, 1,3-bis(2-chloroethyl)1-nitrosourea, and cisplatin. Journal of Pharmacology and Experimental Therapeutics, 304(2), 661–668. https://doi.org/10.1124/jpet.102.043950
