Publication: Orexin neurons track temporal features of blood glucose in behaving mice
Orexin neurons track temporal features of blood glucose in behaving mice
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Viskaitis, P., Tesmer, A. L., Liu, Z., Karnani, M. M., Arnold, M., Donegan, D., Bracey, E., Grujic, N., Patriarchi, T., Peleg-Raibstein, D., & Burdakov, D. (2024). Orexin neurons track temporal features of blood glucose in behaving mice. Nature Neuroscience, 27(7), 1299–1308. https://doi.org/10.1038/s41593-024-01648-w
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Does the brain track how fast our blood glucose is changing? Knowing such a rate of change would enable the prediction of an upcoming state and a timelier response to this new state. Hypothalamic arousal-orchestrating hypocretin/orexin neurons (HONs) have been proposed to be glucose sensors, yet whether they track glucose concentration (proportional tracking) or rate of change (derivative tracking) is unknown. Using simultaneous recordings of HONs and blood glucose in behaving male mice, we found that maximal HON responses occur in co
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- Viskaitis, Paulius
- Tesmer, Alexander L
- Liu, Ziyu
- Karnani, Mahesh M
- Arnold, Myrtha
- Donegan, Dane
- Bracey, Eva
- Grujic, Nikola
- Peleg-Raibstein, Daria
- Burdakov, Denis
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Viskaitis, P., Tesmer, A. L., Liu, Z., Karnani, M. M., Arnold, M., Donegan, D., Bracey, E., Grujic, N., Patriarchi, T., Peleg-Raibstein, D., & Burdakov, D. (2024). Orexin neurons track temporal features of blood glucose in behaving mice. Nature Neuroscience, 27(7), 1299–1308. https://doi.org/10.1038/s41593-024-01648-w
