Chloroquine interference with hemoglobin endocytic trafficking suppresses adaptive heme and iron homeostasis in macrophages: the paradox of an antimalarial agent

Schaer, Christian A; Laczko, Endre; Schoedon, Gabriele; Schaer, Dominik J; Vallelian, Florence

doi:10.5167/uzh-84414

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Schaer, C. A., Laczko, E., Schoedon, G., Schaer, D. J., & Vallelian, F. (2013). Chloroquine interference with hemoglobin endocytic trafficking suppresses adaptive heme and iron homeostasis in macrophages: the paradox of an antimalarial agent. Oxidative Medicine and Cellular Longevity, 2013, 870472. https://doi.org/10.1155/2013/870472

Abstract

The CD163 scavenger receptor pathway for Hb:Hp complexes is an essential mechanism of protection against the toxicity of extracellular hemoglobin (Hb), which can accumulate in the vasculature and within tissues during hemolysis. Chloroquine is a lysosomotropic agent, which has been extensively used as an antimalarial drug in the past, before parasite resistance started to limit its efficacy in most parts of the world. More recent use of chloroquine is related to its immunomodulatory activity in patients with autoimmune diseases, which