Publication: Custom Glycosylation of Cells and Proteins Using Cyclic Carbamate-Derivatized Oligosaccharides
Custom Glycosylation of Cells and Proteins Using Cyclic Carbamate-Derivatized Oligosaccharides
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Whitehead, M. W. J., Khanzhin, N., Borsig, L., & Hennet, T. (2017). Custom Glycosylation of Cells and Proteins Using Cyclic Carbamate-Derivatized Oligosaccharides. Cell Chemical Biology, 24(11), 1336-1346.e3. https://doi.org/10.1016/j.chembiol.2017.08.012
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The structural complexity of glycosylation restrains the functional characterization of glycans. We present a versatile carbohydrate ligation technique based on the reaction of cyclic carbamates with primary amines. Cyclic-carbamate-derivatized carbohydrates can be added to primary amine-containing molecules in aqueous solution to yield glycoconjugates. This method enabled the presentation of carbohydrate epitopes on live animal cells, as shown by the acquisition of E-selectin binding sites on mouse MC-38 cells decorated with 3-fucosy
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- Whitehead, Marek W J
- Khanzhin, Nikolay
- Borsig, Lubor
- Hennet, Thierry
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Whitehead, M. W. J., Khanzhin, N., Borsig, L., & Hennet, T. (2017). Custom Glycosylation of Cells and Proteins Using Cyclic Carbamate-Derivatized Oligosaccharides. Cell Chemical Biology, 24(11), 1336-1346.e3. https://doi.org/10.1016/j.chembiol.2017.08.012