Publication: Epigenetic regulation of myocardial homeostasis, self-regeneration and senescence
Epigenetic regulation of myocardial homeostasis, self-regeneration and senescence
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Matteucci, M., Papini, G., Ciofini, E., Barile, L., & Lionetti, V. (2015). Epigenetic regulation of myocardial homeostasis, self-regeneration and senescence. Current Drug Targets, 16(8), 827–842. https://doi.org/10.2174/1389450116666150630110821
Abstract
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Abstract
The adult myocardium has limited capacity to preserve, renew or rejuvenate itself. The local microenvironment may induce epigenetic changes affecting the survival, proliferation, function and senescence of cardiac cells at rest and following the exposure to different stressors. The cellular response to microenvironment is characterized by the release of ions, oxygen free radicals, auto/paracrine factors and RNAs that drive the magnitude of gene reprogramming through the interaction with specific promoters. The epigenetic alterations m
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- Matteucci, Marco
- Papini, Gaia
- Ciofini, Enrica
- Barile, Lucio
- Lionetti, Vincenzo
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Matteucci, M., Papini, G., Ciofini, E., Barile, L., & Lionetti, V. (2015). Epigenetic regulation of myocardial homeostasis, self-regeneration and senescence. Current Drug Targets, 16(8), 827–842. https://doi.org/10.2174/1389450116666150630110821
