Publication: Gut microbiota modulate T cell trafficking into human colorectal cancer
Gut microbiota modulate T cell trafficking into human colorectal cancer
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Cremonesi, E., Governa, V., Garzon, J. F. G., Mele, V., Amicarella, F., Muraro, M. G., Trella, E., Galati-Fournier, V., Oertli, D., Däster, S. R., Droeser, R. A., Weixler, B., Bolli, M., Rosso, R., Nitsche, U., Khanna, N., Egli, A., Keck, S., Slotta-Huspenina, J., … Iezzi, G. (2018). Gut microbiota modulate T cell trafficking into human colorectal cancer. Gut, 67(11), 1984–1994. https://doi.org/10.1136/gutjnl-2016-313498
Abstract
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Abstract
OBJECTIVE Tumour-infiltrating lymphocytes (TILs) favour survival in human colorectal cancer (CRC). Chemotactic factors underlying their recruitment remain undefined. We investigated chemokines attracting T cells into human CRCs, their cellular sources and microenvironmental triggers. DESIGN Expression of genes encoding immune cell markers, chemokines and bacterial 16S ribosomal RNA (16SrRNA) was assessed by quantitative reverse transcription-PCR in fresh CRC samples and corresponding tumour-free tissues. Chemokine receptor expressi
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- Cremonesi, Eleonora
- Governa, Valeria
- Garzon, Jesus Francisco Glaus
- Mele, Valentina
- Amicarella, Francesca
- Muraro, Manuele Giuseppe
- Trella, Emanuele
- Galati-Fournier, Virginie
- Oertli, Daniel
- Däster, Silvio Raffael
- Droeser, Raoul A
- Weixler, Benjamin
- Bolli, Martin
- Rosso, Raffaele
- Nitsche, Ulrich
- Khanna, Nina
- Egli, Adrian
- Keck, Simone
- Slotta-Huspenina, Julia
- Terracciano, Luigi M
- Zajac, Paul
- Spagnoli, Giulio Cesare
- Eppenberger-Castori, Serenella
- Janssen, Klaus-Peter
- Borsig, Lubor
- Iezzi, Giandomenica
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Cremonesi, E., Governa, V., Garzon, J. F. G., Mele, V., Amicarella, F., Muraro, M. G., Trella, E., Galati-Fournier, V., Oertli, D., Däster, S. R., Droeser, R. A., Weixler, B., Bolli, M., Rosso, R., Nitsche, U., Khanna, N., Egli, A., Keck, S., Slotta-Huspenina, J., … Iezzi, G. (2018). Gut microbiota modulate T cell trafficking into human colorectal cancer. Gut, 67(11), 1984–1994. https://doi.org/10.1136/gutjnl-2016-313498
