Publication: Control and signal processing by transcriptional interference
Control and signal processing by transcriptional interference
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Buetti-Dinh, A., Ungricht, R., Kelemen, J. Z., Shetty, C., Ratna, P., & Becskei, A. (2009). Control and signal processing by transcriptional interference. Molecular Systems Biology, 5, 300. https://doi.org/10.1038/msb.2009.61
Abstract
Abstract
Abstract
A transcriptional activator can suppress gene expression by interfering with transcription initiated by another activator. Transcriptional interference has been increasingly recognized as a regulatory mechanism of gene expression. The signals received by the two antagonistically acting activators are combined by the polymerase trafficking along the DNA. We have designed a dual-control genetic system in yeast to explore this antagonism systematically. Antagonism by an upstream activator bears the hallmarks of competitive inhibition, wh
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Creators (Authors)
- Buetti-Dinh, A
- Ungricht, R
- Kelemen, J Z
- Shetty, C
- Ratna, P
- Becskei, A
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Citations
Buetti-Dinh, A., Ungricht, R., Kelemen, J. Z., Shetty, C., Ratna, P., & Becskei, A. (2009). Control and signal processing by transcriptional interference. Molecular Systems Biology, 5, 300. https://doi.org/10.1038/msb.2009.61
