Predniso(lo)ne Dosage and Chance of Remission in Patients With Autoimmune Hepatitis

Pape, Simon; Gevers, Tom J G; Belias, Michail; Mustafajev, Ilyas F; Vrolijk, Jan Maarten; van Hoek, Bart; Bouma, Gerd; van Nieuwkerk, Carin M J; Hartl, Johannes; Schramm, Christoph; Lohse, Ansgar W; Taubert, Richard; Jaeckel, Elmar; Manns, Michael P; Papp, Maria; Stickel, Felix; Heneghan, Michael A; Drenth, Joost P H

doi:10.1016/j.cgh.2018.12.035

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Pape, S., Gevers, T. J. G., Belias, M., Mustafajev, I. F., Vrolijk, J. M., van Hoek, B., Bouma, G., van Nieuwkerk, C. M. J., Hartl, J., Schramm, C., Lohse, A. W., Taubert, R., Jaeckel, E., Manns, M. P., Papp, M., Stickel, F., Heneghan, M. A., & Drenth, J. P. H. (2019). Predniso(lo)ne Dosage and Chance of Remission in Patients With Autoimmune Hepatitis. Clinical Gastroenterology and Hepatology, 17(10), 2068-2075.e2. https://doi.org/10.1016/j.cgh.2018.12.035

Abstract

BACKGROUND & AIMS Patients with autoimmune hepatitis (AIH) commonly receive induction therapy with predniso(lo)ne followed by maintenance therapy with azathioprine. European Association for Study of the Liver clinical practice guidelines advise a predniso(lo)ne dose range of 0.50-1 mg/kg/day, which leaves room for practice variation. We performed a multicenter study to determine the efficacy of different dose ranges of predniso(lo)ne induction therapy in a large European cohort of patients with AIH. METHODS We performed a retrospectiv