Publication: Transcriptional Response in Human Jurkat T Lymphocytes to a near Physiological Hypergravity Environment and to One Common in Routine Cell Culture Protocols
Transcriptional Response in Human Jurkat T Lymphocytes to a near Physiological Hypergravity Environment and to One Common in Routine Cell Culture Protocols
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Vahlensieck, C., Thiel, C. S., Mosimann, M., Bradley, T., Caldana, F., Polzer, J., Lauber, B. A., & Ullrich, O. (2023). Transcriptional Response in Human Jurkat T Lymphocytes to a near Physiological Hypergravity Environment and to One Common in Routine Cell Culture Protocols. International Journal of Molecular Sciences, 24, 1351. https://doi.org/10.3390/ijms24021351
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Cellular effects of hypergravity have been described in many studies. We investigated the transcriptional dynamics in Jurkat T cells between 20 s and 60 min of 9 g hypergravity and characterized a highly dynamic biphasic time course of gene expression response with a transition point between rapid adaptation and long-term response at approximately 7 min. Upregulated genes were shifted towards the center of the nuclei, whereby downregulated genes were shifted towards the periphery. Upregulated gene expression was mostly located on chro
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- Vahlensieck, Christian
- Thiel, Cora Sandra
- Mosimann, Meret
- Bradley, Timothy
- Caldana, Fabienne
- Polzer, Jennifer
- Lauber, Beatrice Astrid
- Ullrich, Oliver
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Vahlensieck, C., Thiel, C. S., Mosimann, M., Bradley, T., Caldana, F., Polzer, J., Lauber, B. A., & Ullrich, O. (2023). Transcriptional Response in Human Jurkat T Lymphocytes to a near Physiological Hypergravity Environment and to One Common in Routine Cell Culture Protocols. International Journal of Molecular Sciences, 24, 1351. https://doi.org/10.3390/ijms24021351
