Publication: Versican V2 and the central inhibitory domain of Nogo-A inhibit neurite growth via p75NTR/NgR-independent pathways that converge at RhoA
Versican V2 and the central inhibitory domain of Nogo-A inhibit neurite growth via p75NTR/NgR-independent pathways that converge at RhoA
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Schweigreiter, R., Walmsley, A. R., Niederöst, B., Zimmermann, D. R., Oertle, T., Casademunt, E., Frentzel, S., Dechant, G., Mir, A., & Bandtlow, C. E. (2004). Versican V2 and the central inhibitory domain of Nogo-A inhibit neurite growth via p75NTR/NgR-independent pathways that converge at RhoA. Molecular and Cellular Neurosciences, 27(2), 163–174. https://doi.org/10.1016/j.mcn.2004.06.004
Abstract
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Myelin is a major obstacle for regenerating nerve fibers of the adult mammalian central nervous system (CNS). Several proteins including Nogo-A, myelin-associated glycoprotein (MAG), oligodendrocyte myelin glycoprotein (OMgp) and the chondroitin-sulfate proteoglycan (CSPG) Versican V2 have been identified as inhibitory components present in CNS myelin. MAG, OMgp as well as the Nogo specific domain Nogo-66 exert their inhibitory activity by binding to a neuronal receptor complex containing the Nogo-66 receptor NgR and the neurotrophin
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- Schweigreiter, Rüdiger
- Walmsley, Adrian R
- Niederöst, Barbara
- Zimmermann, Dieter R
- Oertle, Thomas
- Casademunt, Elisabeth
- Frentzel, Stefan
- Dechant, Georg
- Mir, Anis
- Bandtlow, Christine E
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Schweigreiter, R., Walmsley, A. R., Niederöst, B., Zimmermann, D. R., Oertle, T., Casademunt, E., Frentzel, S., Dechant, G., Mir, A., & Bandtlow, C. E. (2004). Versican V2 and the central inhibitory domain of Nogo-A inhibit neurite growth via p75NTR/NgR-independent pathways that converge at RhoA. Molecular and Cellular Neurosciences, 27(2), 163–174. https://doi.org/10.1016/j.mcn.2004.06.004
