Publication: Dupilumab‐induced eosinophilia in patients with diffuse type 2 chronic rhinosinusitis
Dupilumab‐induced eosinophilia in patients with diffuse type 2 chronic rhinosinusitis
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Ryser, F. S., Yalamanoglu, A., Valaperti, A., Brühlmann, C., Mauthe, T., Traidl, S., Soyka, M. B., & Steiner, U. C. (2023). Dupilumab‐induced eosinophilia in patients with diffuse type 2 chronic rhinosinusitis. Allergy, 78(10), 2712–2723. https://doi.org/10.1111/all.15844
Abstract
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BackgroundDupilumab, a monoclonal anti‐IL‐4Rα antibody, is approved for several type 2 mediated inflammatory diseases like asthma, atopic dermatitis, and diffuse type 2 chronic rhinosinusitis (CRS). Clinical studies had reported a transient increase in blood eosinophils during dupilumab therapy.This study aimed to assess the impact of elevated blood eosinophils on clinical outcome and to investigate the cause of high blood eosinophil levels under dupilumab therapy.MethodsPatients suffering from diffuse type 2 CRS treated with dupiluma
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- Ryser, Fabio S
- Yalamanoglu, Ayla
- Valaperti, Alan
- Brühlmann, Catrin
- Mauthe, Tina
- Traidl, Stephan
- Soyka, Michael B
- Steiner, Urs C
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Ryser, F. S., Yalamanoglu, A., Valaperti, A., Brühlmann, C., Mauthe, T., Traidl, S., Soyka, M. B., & Steiner, U. C. (2023). Dupilumab‐induced eosinophilia in patients with diffuse type 2 chronic rhinosinusitis. Allergy, 78(10), 2712–2723. https://doi.org/10.1111/all.15844
