Publication: The Evolution of Virulence in RNA Viruses under a Competition–Colonization Trade-Off
The Evolution of Virulence in RNA Viruses under a Competition–Colonization Trade-Off
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Delgado-Eckert, E., Ojosnegros, S., & Beerenwinkel, N. (2011). The Evolution of Virulence in RNA Viruses under a Competition–Colonization Trade-Off. Bulletin of Mathematical Biology, 73, 1881–1908. https://doi.org/10.1007/s11538-010-9596-2
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RNA viruses exist in large intra-host populations which display great genotypic and phenotypic diversity. We analyze a model of viral competition between two viruses infecting a constantly replenished cell pool. We assume a trade-off between the ability of the virus to colonize new cells (cell killing rate or virulence) and its local competitiveness (replicative success within coinfected cells). We characterize the conditions that allow for viral spread by means of the basic reproductive number and show that a local coexistence equili
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- Delgado-Eckert, Edgar
- Ojosnegros, Samuel
- Beerenwinkel, Niko
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Delgado-Eckert, E., Ojosnegros, S., & Beerenwinkel, N. (2011). The Evolution of Virulence in RNA Viruses under a Competition–Colonization Trade-Off. Bulletin of Mathematical Biology, 73, 1881–1908. https://doi.org/10.1007/s11538-010-9596-2
