Publication: Different infectivity of HIV-1 strains is linked to number of envelope trimers required for entry
Different infectivity of HIV-1 strains is linked to number of envelope trimers required for entry
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Brandenberg, O. F., Magnus, C., Rusert, P., Regoes, R. R., & Trkola, A. (2015). Different infectivity of HIV-1 strains is linked to number of envelope trimers required for entry. PLoS Pathogens, 11(1), e1004595. https://doi.org/10.1371/journal.ppat.1004595
Abstract
Abstract
Abstract
HIV-1 enters target cells by virtue of envelope glycoprotein trimers that are incorporated at low density in the viral membrane. How many trimers are required to interact with target cell receptors to mediate virus entry, the HIV entry stoichiometry, still awaits clarification. Here, we provide estimates of the HIV entry stoichiometry utilizing a combined approach of experimental analyses and mathematical modeling. We demonstrate that divergent HIV strains differ in their stoichiometry of entry and require between 1 to 7 trimers, with
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- Brandenberg, Oliver F
- Magnus, Carsten
- Rusert, Peter
- Regoes, Roland R
- Trkola, Alexandra
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Citations
Brandenberg, O. F., Magnus, C., Rusert, P., Regoes, R. R., & Trkola, A. (2015). Different infectivity of HIV-1 strains is linked to number of envelope trimers required for entry. PLoS Pathogens, 11(1), e1004595. https://doi.org/10.1371/journal.ppat.1004595
