Publication: Enhanced intimal thickening of expanded polytetrafluoroethylene grafts coated with fibrin or fibrin-releasing vascular endothelial growth factor in the pig carotid artery interposition model
Enhanced intimal thickening of expanded polytetrafluoroethylene grafts coated with fibrin or fibrin-releasing vascular endothelial growth factor in the pig carotid artery interposition model
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Walpoth, B. H., Zammaretti, P., Cikirikcioglu, M., Khabiri, E., Djebaili, M. K., Pache, J. C., Tille, J. C., Aggoun, Y., Morel, D., Kalangos, A., Hubbell, J. A., & Zisch, A. H. (2007). Enhanced intimal thickening of expanded polytetrafluoroethylene grafts coated with fibrin or fibrin-releasing vascular endothelial growth factor in the pig carotid artery interposition model. Journal of Thoracic and Cardiovascular Surgery, 133(5), 1163–1170. https://doi.org/10.1016/j.jtcvs.2007.01.029
Abstract
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OBJECTIVE: Intimal hyperplasia and surface thrombogenicity are major factors in the high failure rate of synthetic small-diameter bypass grafts. Vascular endothelial growth factor is a potent stimulus for endothelial growth, and its provision in a fibrin matrix coating at the luminal graft surface may hold a key to spontaneous graft endothelialization and improved graft patency. METHODS: Pigs underwent bilateral carotid artery interposition of expanded polytetrafluoroethylene grafts either impregnated with fibrin (n = 11)--engineered
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- Walpoth, B H
- Zammaretti, P
- Cikirikcioglu, M
- Khabiri, E
- Djebaili, M K
- Pache, J C
- Tille, J C
- Aggoun, Y
- Morel, D
- Kalangos, A
- Hubbell, J A
- Zisch, A H
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Walpoth, B. H., Zammaretti, P., Cikirikcioglu, M., Khabiri, E., Djebaili, M. K., Pache, J. C., Tille, J. C., Aggoun, Y., Morel, D., Kalangos, A., Hubbell, J. A., & Zisch, A. H. (2007). Enhanced intimal thickening of expanded polytetrafluoroethylene grafts coated with fibrin or fibrin-releasing vascular endothelial growth factor in the pig carotid artery interposition model. Journal of Thoracic and Cardiovascular Surgery, 133(5), 1163–1170. https://doi.org/10.1016/j.jtcvs.2007.01.029
