Publication: Long-range Ca2+ waves transmit brain-damage signals to microglia
Long-range Ca2+ waves transmit brain-damage signals to microglia
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Sieger, D., Moritz, C., Ziegenhals, T., Prykhozhij, S., & Peri, F. (2012). Long-range Ca2+ waves transmit brain-damage signals to microglia. Developmental Cell, 22(6), 1138–1148. https://doi.org/10.1016/j.devcel.2012.04.012
Abstract
Abstract
Abstract
Microglia are the resident phagocytes of the brain that are responsible for the clearance of injured neurons, an essential step in subsequent tissue regeneration. How death signals are controlled both in space and time to attract these cells toward the site of injury is a topic of great interest. To this aim, we have used the optically transparent zebrafish larval brain and identified rapidly propagating Ca2+ waves that determine the range of microglial responses to neuronal cell death. We show that while Ca2+-mediated microglial resp
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Creators (Authors)
- Sieger, Dirk
- Moritz, Christian
- Ziegenhals, Thomas
- Prykhozhij, Sergey
- Peri, Francesca
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Sieger, D., Moritz, C., Ziegenhals, T., Prykhozhij, S., & Peri, F. (2012). Long-range Ca2+ waves transmit brain-damage signals to microglia. Developmental Cell, 22(6), 1138–1148. https://doi.org/10.1016/j.devcel.2012.04.012
