Publication: Plasticity Related Gene 3 (PRG3) overcomes myelin-associated growth inhibition and promotes functional recovery after spinal cord injury
Plasticity Related Gene 3 (PRG3) overcomes myelin-associated growth inhibition and promotes functional recovery after spinal cord injury
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Broggini, T., Schnell, L., Ghoochani, A., Mateos, J. M., Buchfelder, M., Wiendieck, K., Schäfer, M. K., Eyupoglu, I. Y., & Savaskan, N. E. (2016). Plasticity Related Gene 3 (PRG3) overcomes myelin-associated growth inhibition and promotes functional recovery after spinal cord injury. Aging, 8(10), 2463–2487. https://doi.org/10.18632/aging.101066
Abstract
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Abstract
The Plasticity Related Gene family covers five, brain-specific, transmembrane proteins (PRG1-5, also termed LPPR1-5) that operate in neuronal plasticity during development, aging and brain trauma. Here we investigated the role of the PRG family on axonal and filopodia outgrowth. Comparative analysis revealed the strongest outgrowth induced by PRG3 (LPPR1). During development, PRG3 is ubiquitously located at the tip of neuronal processes and at the plasma membrane and declines with age. In utero electroporation of PRG3 induced dendriti
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- Broggini, Thomas
- Schnell, Lisa
- Ghoochani, Ali
- Buchfelder, Michael
- Wiendieck, Kurt
- Schäfer, Michael K
- Eyupoglu, Ilker Y
- Savaskan, Nicolai E
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Broggini, T., Schnell, L., Ghoochani, A., Mateos, J. M., Buchfelder, M., Wiendieck, K., Schäfer, M. K., Eyupoglu, I. Y., & Savaskan, N. E. (2016). Plasticity Related Gene 3 (PRG3) overcomes myelin-associated growth inhibition and promotes functional recovery after spinal cord injury. Aging, 8(10), 2463–2487. https://doi.org/10.18632/aging.101066
