Publication: Cabozantinib and Tivantinib, but Not INC280, Induce Antiproliferative and Antimigratory Effects in Human Neuroendocrine Tumor Cells in vitro: Evidence for 'Off-Target' Effects Not Mediated by c-Met Inhibition
Cabozantinib and Tivantinib, but Not INC280, Induce Antiproliferative and Antimigratory Effects in Human Neuroendocrine Tumor Cells in vitro: Evidence for 'Off-Target' Effects Not Mediated by c-Met Inhibition
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Reuther, C., Heinzle, V., Spampatti, M., Vlotides, G., de Toni, E., Spöttl, G., Maurer, J., Nölting, S., Göke, B., & Auernhammer, C. J. (2016). Cabozantinib and Tivantinib, but Not INC280, Induce Antiproliferative and Antimigratory Effects in Human Neuroendocrine Tumor Cells in vitro: Evidence for “Off-Target” Effects Not Mediated by c-Met Inhibition. Neuroendocrinology, 103(3–4), 383–401. https://doi.org/10.1159/000439431
Abstract
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BACKGROUND/AIMS
The hepatocyte growth factor/transmembrane tyrosine kinase receptor c-Met has been defined as a potential target in antitumoral treatment of various carcinomas. We aimed to investigate the direct effect of c-Met inhibition on neuroendocrine tumor cells in vitro.
METHODS
The effects of the multi-tyrosine kinase inhibitors cabozantinib and tivantinib and of the highly specific c-Met inhibitor INC280 were investigated in human pancreatic neuroendocrine BON1, bronchopulmonary NCI-H727 and midgut GOT1 cells in vitro.
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Creators (Authors)
- Reuther, Clemens
- Heinzle, Vera
- Spampatti, Matilde
- Vlotides, George
- de Toni, Enrico
- Spöttl, Gerald
- Maurer, Julian
- Nölting, Svenja
- Göke, Burkhard
- Auernhammer, Christoph J
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Citations
Reuther, C., Heinzle, V., Spampatti, M., Vlotides, G., de Toni, E., Spöttl, G., Maurer, J., Nölting, S., Göke, B., & Auernhammer, C. J. (2016). Cabozantinib and Tivantinib, but Not INC280, Induce Antiproliferative and Antimigratory Effects in Human Neuroendocrine Tumor Cells in vitro: Evidence for “Off-Target” Effects Not Mediated by c-Met Inhibition. Neuroendocrinology, 103(3–4), 383–401. https://doi.org/10.1159/000439431
