Publication: Ubiquinone accumulation improves osmotic-stress tolerance in Escherichia coli
Ubiquinone accumulation improves osmotic-stress tolerance in Escherichia coli
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Sévin, D. C., & Sauer, U. (2014). Ubiquinone accumulation improves osmotic-stress tolerance in Escherichia coli. Nature Chemical Biology, 10(4), 266–272. https://doi.org/10.1038/NCHEMBIO.1437
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Bacteria are thought to cope with fluctuating environmental solute concentrations primarily by adjusting the osmolality of their cytoplasm. To obtain insights into underlying metabolic adaptions, we analyzed the global metabolic response of Escherichia coli to sustained hyperosmotic stress using non-targeted mass spectrometry. We observed that 52% of 1,071 detected metabolites, including known osmoprotectants, changed abundance with increasing salt challenge. Unexpectedly, unsupervised data analysis revealed a substantial increase of
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- Sévin, Daniel C
- Sauer, Uwe
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Sévin, D. C., & Sauer, U. (2014). Ubiquinone accumulation improves osmotic-stress tolerance in Escherichia coli. Nature Chemical Biology, 10(4), 266–272. https://doi.org/10.1038/NCHEMBIO.1437
